The AIDS and Cancer Specimen Resource (ACSR) biorepository includes biospecimens from persons with HIV who have been diagnosed with a wide spectrum of HIV related diseases, particularly cancers, pre and post-HAART. The ACSR’s mission is to acquire, store, and equitably distribute these tumor tissues and biological fluids along with associated clinical data to investigators conducting HIV related research.
The current inventory include s large well-annotated special collections from domestic and sub-Saharan African HIV related studies, from completed AIDS Malignancy Consortium clinical trials, and from multisite autopsies. In addition, the ACSR’s technology core has created a number of cancer-specific and multisite autopsy tissue microarrays (TMAs) suitable for screening studies. TMAs are assembled from FFPE blocks that have been re-reviewed by ACSR pathologists for confirmation of diagnosis, % tumor and tissue quality, and marked for optimal sites for core extraction. TMA construction adheres to strict quidelines and SOPs that ensure a high-quality product to support investigator’s research. DNA and RNA have been extracted from core blocks for several TMAs to facilitate follow-up research. Fit for purpose studies conducted for quality of protein and nucleic acids derived from archival FFPE blocks in our inventory have confirmed the suitability of archival FFPE biospecimens for tumor DNA/RNA studies.
Details about our biospecimen inventory including our collections and TMAs can be found at “Biospecimens” and information on how to apply for biospecimens at “Request Specimens”. Aperio Images for each TMA can be viewed at “ACSR Digital Library.” Please explore our “Frequently Asked Questions” page for commonly asked questions.
Use of biospecimens
Biospecimens from the ACSR are provided to approved investigators for research purposes only. Biospecimens and their products shall not be sold or used for commercial purposes, nor will biospecimens be distributed further to third parties for purposes of shared research, sale or producing for sale, cells or cell products. The biospecimens are provided as a service to the research community without warranty of merchantability or fitness for a particular purpose or any other warranty, expressed or implied.