Using ACSR samples, A. Maguire et al. published their report on “Enhanced DNA repair and genomic stability identify a novel HIV-related diffuse large B-cell lymphoma signature” (Int J Cancer. 2019 Dec 1;145(11):3078-3088). Diffuse large B cell lymphoma (DLBCL) is an AIDS-defining illness, and also follows a more aggressive clinical course and frequently presents at advanced stages in patients living with or without HIV. Therefore, understanding the biology of DLBCL in HIV(+) patients is important to planning the best treatment options. In this study, the authors show that HIV(+) DLBCL is a distinct cancer entity, which is different from HIV(-) DLBCL; with an increased ability to proliferate and better genome stability. Additional work is on-going.